
Dimethyl sulfoxide (DMSO), MF: C₂H₆OS MW: 78.13, a sulfur-containing organic compound and polar aprotic solvent, is a hygroscopic, flammable liquid characterized by high polarity, high boiling point, and aprotic nature. It possesses strong solvency, chemical stability, and unique biological permeability, earning it the widespread designation as the “universal solvent.”
| Item | Specification |
| Melting point | 18.4°C |
| Boiling point | 189°C (lit.) |
| Density | 1.100 g/mL at 20°C |
| Vapor Density | 2.7 (vs air) |
| Vapor Pressure | 0.42 mmHg (20°C) |
| Refractive Index | n20/D 1.479 (lit.) |
| Flash Point | 192°F |
| Acidity Coefficient (pKa) | 35 (at 25°C) |
| Relative polarity | 0.444 |
| Freezing point | 18.4°C |
| Odor | Slight garlic odor |
| Solubility | Infinitely miscible with water, ethanol, diethyl ether, acetone, etc. Dissolves most organic compounds, inorganic salts, and polymers. |
Pharmaceutical-grade dimethyl sulfoxide (DMSO):
– Used as a solvent, co-solvent, or permeation enhancer in oral solutions, ointments, injections, and other formulations.
– Serves as a cryoprotectant for cell cryopreservation, one of the most commonly used cryoprotectants in clinical cell therapy.
– Employed alone or in combination with other ingredients for local therapeutic adjuncts in muscle pain relief, arthritis treatment, etc.
Electronic-grade dimethyl sulfoxide:
– Semiconductor cleaning: 99.99% DMSO is used for cleaning semiconductor wafers.
– Lithium battery electrolyte additive: In lithium-ion batteries, small amounts of DMSO serve as a solvent or additive in electrolytes to enhance ionic conductivity.
Industrial-grade dimethyl sulfoxide:
– As a polar non-protonic solvent, it promotes nucleophilic substitution, redox reactions, and other processes.
– Used to dissolve or swell polymeric compounds.
– Serves as a solvent or co-solvent in coatings and inks, suitable for complex systems requiring dissolution of multiple resins.
Research and analytical applications:
– Used as a mobile phase additive in chromatography.
– In environmental monitoring or food testing, used to extract organic pollutants from solid samples.
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