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Cas 6674-22-2(1,8-Diazabicyclo [5.4.0] undec-7-ene , DBU), IUPAC name: 2,3,4,6,7,8,9,10-octahydropyrimidin[1,2-a]azepine) is a bicyclic amine and a super-strong organic base with the molecular formula C9H16N2, molecular weight 152.24. At room temperature, it is a colorless to pale yellow transparent liquid with a faint amine odor. It is soluble in water and most organic solvents, with a pKa value of approximately 24.3 (in acetonitrile). It serves as a core non-nucleophilic strong base and highly efficient catalyst in organic synthesis, and is widely used in the pharmaceutical, polymer materials, and fine chemicals industries.
| Item | Specification |
| Melting Point | -70°C |
| Boiling Point | 80–83°C at 0.6 mmHg |
| Density | 1.019–1.04 g/cm³ (20°C) |
| Flash point | 109–116°C |
| Vapor pressure | 5.3 mmHg (37.7°C) |
| Refractive index | 1.521–1.523 (20°C) |
| PKa | 24.3 (in acetonitrile, conjugate acid) |
| Solubility | Highly soluble in water (>500 g/L); miscible with ethanol, acetone, benzene, etc. |
| Stability | Store sealed at room temperature; avoid contact with strong acids and strong oxidizing agents; stable in water. |
Organic Synthesis: Acts as a non-nucleophilic strong base to catalyze condensation, elimination, and dehydration reactions; also used as a deprotection reagent for functional groups.
Polymer Processing: Acts as a curing agent for epoxy resins and a catalyst for polyurethane synthesis, regulating polymerization reaction rates and product properties.
Pharmaceutical and Chemical Industry: DBU is used in the synthesis of drug intermediates such as cephalosporin antibiotics to optimize synthetic routes and product purity.
Industrial Additives: DBU is used in the preparation of metal corrosion inhibitors and material surface treatment agents; also used in the synthesis of ionic liquids and surfactants.
Jinan Jinbang Chemical Co., Ltd., strategically located within the New Materials Industrial Park in Tianqiao District, Jinan City, Shandong Province, stands as a prominent chemical innovator since its establishment in 2015. Operating from a modern, expansive 37,500 m² manufacturing facility, we are dedicated to the research & development, production, and global distribution of high-performance chemical solutions.
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