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2-Butyl-4-chloro-5-formylimidazole is a crucial organic synthesis intermediate. It appears as a white to yellow crystalline powder with high hygroscopicity. Molecular formula: C8H11ClN2O; Molecular weight: 186.64. Its molecule contains an imidazole ring and an aldehyde group, featuring a stable three-dimensional structure and moderate polarity.
| Item | Specification |
| Melting point | 97–100°C (lit.) |
| Boiling point | 384.1±22.0°C at 760 mmHg |
| Density | 1.240 g/cm³ |
| Vapour pressure | 0.001 Pa at 25°C |
| Flash point | 186.1±22.3 °C |
| Refractive Index | 1.568 |
| Acidity coefficient (pKa) | 8.87±0.10 (Predicted) |
| Surface Tension | 58.3 mN/m (1.2 g/L, 20°C) |
| Solubility | Sparingly soluble in water; soluble in various organic solvents (e.g., ethanol, ethyl acetate, dichloromethane, DMSO). |
2-Butyl-4-chloro-5-formylimidazole is a key intermediate for synthesizing sartan antihypertensive drugs, used in the synthesis of losartan potassium (antihypertensive agent).
An important intermediate for multi-step organic synthesis reactions, applicable for synthesizing other bioactive molecules containing imidazole rings.
Serves as a precursor for metal-organic frameworks (MOFs) and coordination polymers in functional material synthesis.
Certain imidazole aldehyde derivatives function as enzyme inhibitors for research into metabolic disorders and immune dysregulation. Additionally, it holds potential applications in dye and fragrance synthesis.
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