
Acetylacetone, also known as diethylacetylmethane or pentanedione, is a derivative of acetone with the mf: C₅H₈O₂ and mw: 100.11. It appears as a colorless to pale yellow transparent liquid. Acetylacetone exhibits unique keto-enol tautomerism and bidentate ligand properties, typically existing as a mixture of enol and ketone tautomers in dynamic equilibrium.
| Item | Specification |
| Melting point | -23°C (lit.) |
| Boiling point | 140.4°C (lit.) |
| Density | 0.975 g/mL at 25°C (lit.) |
| Vapor density | 3.5 (vs air) |
| Vapor pressure | 6 mmHg (20°C) |
| Refractive index | n₂₀/D 1.452 (lit.) |
| Flash point | 66°F |
| Acid dissociation constant (pKa) | 8.9 (at 25°C) |
| Relative polarity | 0.571 |
| Solubility | Sparingly soluble in water, forms azeotropic mixtures with water; readily soluble in organic solvents such as ethanol, diethyl ether, chloroform. |
It is used as an intermediate in synthesizing antibacterial agents, sulfonamide drugs, anticoccidials, and vitamins, as well as a solubilizing agent for pharmaceutical formulations.
2,4-Pentanedione serves as a catalyst for metal complexes, a drying agent in coatings, and an additive in polymer materials.
2,4-Pentanedione is employed in analytical chemistry and extraction, such as metal ion detection reagents, metal extractants, and heavy metal pollution detection and remediation.
Additionally, It serves as a fuel additive, in pesticide synthesis, fragrance synthesis, and lithium battery materials.
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