
Cetyltrimethylammonium Chloride, also known as C16-Trimethylammonium Chloride, is a quaternary ammonium cationic surfactant. MF: C₁₉H₄₂ClN, MW: 320.00. Appearance: white crystalline powder. It exhibits excellent compatibility with cationic, nonionic, and amphoteric surfactants. It exhibits excellent chemical stability, withstanding heat, light, pressure, and strong acids/bases. It possesses outstanding penetration, softening, emulsifying, antistatic, biodegradable, and bactericidal properties.
| Item | Specification |
| Melting point | 232-234°C |
| Boiling Point | 475.54°C |
| Density | 0.968 g/mL at 25°C |
| Vapor Pressure | 0.006 Pa at 25°C |
| Refractive Index | n20/D 1.3778 |
| Flash Point | >110°C |
| Specific gravity | 0.968 |
| CMC | 1.3×10⁻³ mol/L (at 25°C) |
| Solubility | Highly soluble in water, forming clear or slightly turbid solutions; soluble in polar organic solvents such as ethanol and isopropanol; insoluble in non-polar solvents like diethyl ether and petroleum ether. |
Personal Care Sector:
– As a cationic conditioning agent in shampoos and conditioners
– As a germicidal ingredient (0.1%-1% concentration) in body washes, hand soaps, toothpastes, and mouthwashes
– As an emulsifier and stabilizer in creams, lotions, sunscreens, and similar products.
Pharmaceutical and Biotech Applications:
– For disinfecting medical devices and skin/mucous membranes with high bactericidal efficacy.
– As a solubilizer and emulsifier in pharmaceutical formulations to aid dissolution or dispersion of poorly soluble drugs.
– For cell membrane separation, protein extraction and purification, or as a membrane disruptor in DNA extraction.
Industrial and Materials Applications:
– Used as a fabric softener and antistatic agent, as well as a leveling agent in textile printing and dyeing.
– Used for paper sizing and surface treatment, also functions as a sterilant to prevent pulp mold growth.
– As a cationic flocculant for industrial wastewater treatment, while inhibiting bacteria in circulating cooling water.
– Used in metal surface treatment, pesticide emulsifiers, catalyst carriers, etc.
Cetyltrimethylammonium Chloride can serve as a food processing aid, a mobile phase additive for ion-pair chromatography (IPC), and a model compound for surface tension measurement and micelle behavior studies.
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