
Diethylene glycol (MF: C₄H₁₀O₃ MW: 106.12) is produced by reacting ethylene oxide with ethylene glycol. It can undergo esterification reactions with organic acids (e.g., acetic acid, benzoic acid). The ether bond remains chemically stable at room temperature and is resistant to decomposition. However, under strongly acidic conditions or at elevated temperatures (>300°C), ether bond cleavage may occur. Diethylene glycol is widely used in various cosmetics due to its properties: solvent-like solubility, reactive intermediary characteristics, low volatility, and high boiling point.
| Item | Specification |
| Melting point | −10°C (lit.) |
| Boiling point | 245°C (lit.) |
| Density | 1.118 g/mL at 25°C (lit.) |
| Vapor Density | 2.14 (vs air) |
| Vapor Pressure | 0.01 mmHg (20°C) |
| Refractive Index | n20/D 1.447 (lit.) |
| Flash Point | 143°C |
| Acidity Coefficient (pKa) | 14.03 ± 0.10 (Predicted) |
| Relative Polarity | 0.713 |
| PH | 5.5–7.0 (25°C, 50 mg/mL in H₂O) |
| Freezing Point | −10.45°C |
| Viscosity | 35.7 mPa·s (20°C) |
| Solubility | Highly soluble in water; also soluble in organic solvents such as ethanol, diethyl ether, acetone, and ethylene glycol; insoluble in non-polar solvents like benzene, toluene, and petroleum ether. |
Diethylene glycol as a solvent for dissolving film-forming substances in coatings and inks, commonly used in automotive coatings, furniture lacquers, and printing inks (plastic film inks).
In pharmaceuticals and pesticides diethylene glycolas a solvent or co-solvent to dissolve water-insoluble active pharmaceutical ingredients or pesticide technical grades.
Used in small quantities in cosmetics (e.g., face creams, shampoos) as a humectant and solvent.
Serves as a chemical intermediate for synthesizing PEGs of varying molecular weights (e.g., PEG-400, PEG-600), diethylene glycol ethers, and synthetic unsaturated polyester resins.
Used alone or blended with ethylene glycol, leveraging its low freezing point and high boiling point properties as industrial antifreeze.
Blended with water and corrosion inhibitors to produce automotive engine coolant for industrial heavy equipment.
Diethylene glycol is used in textile and papermaking industries as textile auxiliaries (softeners, antistatic agents) and papermaking additives.
Employed as viscosity reducers in drilling fluids and additives in fracturing fluids for oil and gas extraction.
Diethylene glycol is used in small quantities as a solvent for flavorings, aiding in dissolving lipid-soluble components in natural essences to enhance flavor stability and retention time.
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