
Guaiacol (2-methoxyphenol / o-hydroxybenzyl ether) is an aromatic compound containing a phenolic hydroxyl group and a methoxy group. It occurs naturally in guaiac resin, wood distillate, and various plant essential oils. MF: C₇H₈O₂; MW: 124.14. Above 28°C, it is a colorless to pale yellow oily liquid; below 28°C, it is a white crystalline solid. It possesses a distinctive phenolic aroma with smoky and sweet notes and is prone to oxidation and discoloration. It is an important intermediate in the pharmaceutical, fragrance, and dye industries.
| Item | Specification |
| Melting Point | 26-29℃(lit.) |
| Boiling Point | 207.5±29.0℃(760 mmHg) |
| Density | 1.129 g/mL(25℃) |
| Flash point | 82℃ |
| Vapor pressure | 0.11 mmHg(25℃) |
| Refractive index | n²⁰/D 1.543(lit.) |
| Water solubility | 17 g/L (15°C) |
| Stability | Gradually darkens when exposed to air or sunlight |
Flavors and Fragrances:Guaiacol is used to formulate tobacco, edible and daily chemical flavors for fragrance enhancement and fixation, presenting natural woody and vanilla aroma.
Pharmaceutical Raw Materials:Applied as intermediates for expectorant and antitussive drugs, and used in the preparation of medical antibacterial preparations.
Pesticide & Chemical Industry:2-Methoxyphenol is used to synthesize intermediates for plant growth regulators, agricultural insecticides and fungicides.
Food Industry:Methylcatechol serves as food flavor enhancer to improve the taste of baked goods, beverages and condiments.
Fine Chemicals:An important intermediate for synthesizing dyes, resins and antioxidants in organic synthesis.
Daily Care Products:Added in washing and care products for fragrance blending, soothing and antibacterial effects.
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