Hydroxypinacolone Retinoate/HPR

Hydroxyphenanthrene retinoate (HPR), a third-generation retinoic acid derivative (retinoid), is formed by the esterification of retinoic acid with hydroxyphenanthrene and is hailed as a “gentle yet highly effective anti-aging breakthrough.” MF: C₂₆H₃₈O₃, MW: 398.58. Its core advantage lies in the fact that it does not require metabolic conversion by the skin; it can bind directly to cellular retinoic acid receptors (RARs). It is as effective as retinol at the same concentration but with significantly reduced irritation (approximately 1/10 that of traditional retinoic acid) and is about 10 times more stable than retinol. with an activity retention rate exceeding 90% under sunlight.

Hydroxypinacolone retinoate is a retinol derivative that regulates the metabolism of the epidermis and stratum corneum. It combats aging, reduces sebum production, and lightens epidermal pigmentation, thereby preventing skin aging, preventing acne, and brightening the skin to reduce dark spots. While maintaining the powerful efficacy of retinol, it significantly reduces its irritation and is currently used for anti-aging and the prevention of acne recurrence.