
Formamide is an amide derived from formic acid, with the molecular formula CH₃NO and molecular weight 45.04. It serves as a crucial polar non-protonic solvent and a key intermediate in organic synthesis. Its molecular structure incorporates both an amino group (-NH₂) and a carbonyl group (C=O), endowing it with strong solubility, high polarity, and reactivity. It finds extensive application across multiple sectors including chemical engineering, electronics, and pharmaceuticals.
| Item | Specification |
| Melting point | 2–3°C (lit.) |
| Boiling point | 210°C (lit.) |
| Density | 1.134 g/mL at 25°C (lit.) |
| Vapor density | 1.55 (vs air) |
| Vapor pressure | 0.08 mmHg (20°C) |
| Refractive Index | n₂₀/D 1.447 (lit.) |
| Flash Point | 310°F |
| Viscosity | 3.76 mPa·s (20°C) |
| Acidity coefficient (pKa) | 16.50 ± 0.50 (Predicted) |
| Specific gravity | 1.138 (20/20°C) |
| Hygroscopicity | Strongly hygroscopic |
| Solubility | Completely miscible with water, methanol, ethanol, acetone, ethyl acetate and most polar solvents. |
For industrial solvent applications:
– Dissolves polymeric materials such as PAN spinning, polyamide, and polyvinyl chloride (PVC) for producing acrylic fibres, formulating coatings, or manufacturing adhesives.
– Serves as a solvent in homogeneous reaction systems to dissolve inorganic salts resistant to conventional solvents; also employed for extracting and separating mixtures.
For organic synthesis and pharmaceutical intermediates, such as preparing heterocyclic compounds and amide derivatives.
Employed in the electronics and semiconductor industries, such as in photoresist preparation and as a polarity regulator in electrolytes.
Utilised in agriculture for synthesising herbicides and insecticides.
Also applied in chromatography analysis; dissolution and extraction of proteins and nucleic acids; and as a concrete ‘antifreeze agent’.
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