
Methylparaben (MF: C₈H₈O₃, MW: 152.15) is the most commonly used and classic preservative among the p-hydroxybenzoate esters, and is classified as a broad-spectrum antimicrobial agent. It exhibits excellent inhibitory effects against moulds, yeasts and bacteria; its antimicrobial efficacy is minimally affected by pH and it offers high stability, making it a classic preservative widely used in the food, cosmetics and pharmaceutical sectors.
| Item | Specification |
| Melting Point | 125–128 °C (lit.) |
| Boiling Point | 270–275 °C |
| Density | 1.46 g/cm³ |
| Vapor pressure | 0.000005 hPa (20 °C) |
| Refractive index | 1.5204 |
| Flash point | 116.4±12.6 °C |
| Acid dissociation constant (pKa) | pKa 8.15 (H₂O, t=20.0) (Uncertain) |
| Odor | Odourless or with a faint burnt smell. Slight burnt odour |
| Freezing point | 131 °C |
| Merck | 14.6107 |
| Solubility | Freely soluble in organic solvents such as ethanol, diethyl ether and acetone; slightly soluble in water and hot water. |
| Stability | Stable at room temperature; acid- and heat-resistant; not prone to decomposition. |
Cosmetics and personal care: Methylparaben is used as a preservative in products such as face creams, lotions, shampoos, shower gels and facial cleansers to extend shelf life.
Food Industry: Methyl 4-hydroxybenzoate is used in beverages, jams, soy sauce, sauces, pastries, etc., to inhibit the growth of mould and microorganisms.
Pharmaceutical Sector: Used as an antibacterial preservative in pharmaceutical formulations (oral solutions, topical preparations) and also as a pharmaceutical excipient.
Other Industries: Used for preservation and mould prevention in the feed, coatings, adhesives and paper industries.
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