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Poly(D,L Lactide-co-glycolide) (CAS: 26780-50-7) is a linear aliphatic polyester formed by the ring-opening polymerization of two monomers: lactic acid (LA) and glycolic acid (GA). Its molecular formula is (C₃H₄O₂)ₓ(C₂H₂O₂)ᵧ or (C₆H₈O₄・C₄H₄O₄)ₙ, and its molecular weight can be adjusted within the range of 0.5 to 110,000.
PLGA is a white to pale yellow crystalline powder that degrades into lactic acid and glycolic acid, which are ultimately metabolized into CO₂ and water, with no accumulation of toxic byproducts.
| Item | Specification |
| Melting Point | 236°C |
| Boiling Point | N/A |
| Density | 1.34 g/cm³ |
| Flash point | 113°C |
| Tg | 40-60°C |
| Intrinsic viscosity | 1.3–1.7 dL/g (0.1% chloroform, 25°C) |
| Solubility | Soluble in ethyl acetate, chloroform, acetone, and THF |
Pharmaceutical Formulations: Poly(D,L Lactide-co-glycolide) is used as a sustained-release carrier to prepare microspheres, nanoparticles, and implants, enabling long-acting, controlled drug release.
Medical Devices: Processed into absorbable sutures, postoperative anti-adhesion membranes, orthopedic repair components, and tissue engineering scaffolds that degrade in vivo.
Aesthetic Medicine Applications: PLGA is used as biodegradable soft tissue fillers, as well as carriers for the transdermal delivery of active skincare ingredients.
Research and Other Industrial Applications: Cell culture scaffolds for biological research; sustained-release carriers for pesticides and fertilizers in agriculture; and for the production of certain biodegradable polymer products.
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