
Polyglutamic acid (γ-PGA), also known as nattokinase gel or polyglutamic acid, is a water-soluble, biodegradable, non-toxic biopolymer produced through microbial fermentation. It is primarily used for moisturizing, brightening, antibacterial effects, and promoting skin health.
Polyglutamic acid has a wide molecular weight distribution (2 kDa–10,000 kDa) and is classified into different grades based on application: agricultural grade (<20,000), cosmetic/food grade (500,000–700,000), pharmaceutical grade (800,000–1,000,000), and water treatment grade (1,200,000–1,500,000). Its core characteristics include water solubility, biocompatibility, biodegradability, and non-toxicity. The molecular chains contain a large number of free carboxyl groups, endowing it with excellent water absorption, metal chelation capacity, and pH responsiveness.
| Item | Specification |
| Melting Point | N/A |
| Boiling Point | N/A |
| Thermal stability | Begins to decompose at temperatures above 120°C; non-volatile; |
| PH | 5.0–8.0 (1% aqueous solution) |
| Flash point | N/A |
| Solubility | Highly soluble in water, forming a clear, viscous solution; insoluble in organic solvents. |
| Properties | Anionic polyelectrolyte; can be cross-linked to form hydrogels; biodegradable. |
Cosmetics: As a highly effective moisturizer, it is used in creams, serums, masks, lotions, and other products to lock in skin moisture, improve dryness, and enhance product texture and stability.
Food: polyglutamic acid is used as a thickener, stabilizer, and moisturizer in beverages, dairy products, and pastries to improve texture, extend shelf life, and as a dietary fiber supplement.
Agriculture: γ-PGA is used as a water-retaining agent in crop cultivation to improve soil water and fertilizer retention, promote crop growth, and reduce water waste.
Pharmaceuticals: polyglutamic acid powder is used as a drug carrier to encapsulate drugs, improving solubility and bioavailability. It can also be used in wound dressings and tissue engineering materials.
Water Treatment: γ-PGA is used as a flocculant in industrial wastewater and drinking water treatment to adsorb impurities, improve water quality, and prevent secondary pollution.
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