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Sebacoyl Chloride (MF: C₁₀H₁₆Cl₂O₂ MW: 239.14) is a significant organic synthesis intermediate. It is a derivative of sebacic acid, produced by reacting its carboxyl group with chlorinating reagents such as thionyl chloride. Its molecular structure contains two acyl chloride groups (-COCl), conferring high reactivity and making it a key raw material for synthesising numerous organic compounds.
| Item | Specification |
| Melting point | -2.5°C |
| Boiling point | 220°C |
| Density | 1.121 g/mL at 25°C (lit.) |
| Vapor pressure | 0.000787 mmHg at 25°C) |
| Refractive Index | n₂₀/D 1.468 (lit.) |
| Flash Point | >230°F |
| Specific gravity | 1.121 |
| Solubility | Freely soluble in hydrocarbons and ethers, but reacts violently with water. |
Polymer synthesis
– Condenses with hexamethylenediamine to form nylon-6,10, used in engineering plastics, fibres and films.
– Employed in synthesising polyurethane coatings to enhance mechanical properties and chemical resistance.
Used to form amide or ester bonds in complex molecules such as antibiotics and anticancer drugs.
Fine Chemicals
– Reacts with alcohols to form ester surfactants for detergents, emulsifiers, etc.
– Participates in Friedel-Crafts acylation of aromatic compounds to prepare fragrance intermediates.
Other Applications
– Serves as an activating agent in organic synthesis for preparing anhydrides, ketones, and other compounds.
– Functions as a cross-linking agent in coating materials to enhance coating hardness and durability.
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