
Tetramethylethylenediamine (TMEDA/TEMED) is a colorless, transparent liquid with a faint ammonia odor. It belongs to the class of aliphatic tertiary diamines, exhibits strong basicity and bidentate coordination ability, and is miscible with water, alcohols, and most organic solvents. It serves as a core ligand, catalyst, and cross-linking agent in the fields of organic synthesis, polymer materials, and biochemistry, and is widely used in metal-organic reactions, polyurethane foaming, and polyacrylamide gel electrophoresis.
| Item | Specification |
| Melting Point | -55°C(lit.) |
| Boiling Point | 120-122°C(lit.) |
| Density | 0.775 g/mL at 20°C(lit.) |
| Flash point | 50°F(10°C) |
| Vapor pressure | 21 hPa(20°C) |
| Refractive index | n 20/D 1.4179(lit.) |
| Solubility | Miscible with water; soluble in most organic solvents. |
| Sensitivity | Hygroscopic; absorbs carbon dioxide. |
Organic Synthesis: Tetramethylethylenediamine is used as a ligand in organometallic reactions and as a basic catalyst to activate reaction systems, catalyzing coupling, condensation, and ring-opening reactions.
Polymer Science: Serves as a foaming agent for polyurethane and can initiate gelation polymerization; it is a common reagent in biochemical electrophoresis experiments.
Fine Chemicals: Tetramethylethylenediamine is used in the synthesis of pharmaceutical intermediates, quaternary ammonium salts, and ionic liquids; also used to prepare water treatment corrosion inhibitors and scale inhibitors.
Other Applications: Serves as a specialty reaction solvent and can be added to battery electrolytes to improve the system’s conductivity and stability.
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