Tosyl Isocyanate

Cas 4083-64-1

Tosyl Isocyanate Cas 4083-64-1

Chemical Properties Of Tosyl Isocyanate Cas 4083-64-1

Tosyl Isocyanate (PTSI), MF: C₈H₇NO₃S, MW: 197.21, is an important organic synthetic reagent containing two reactive groups in its molecular structure: a p-toluenesulfonyl group and an isocyanate group. The reactivity of the isocyanate carbon is significantly enhanced by the adjacent tosyl group, making it an efficient reagent for the synthesis of carbamates, urea derivatives, and other compounds. PTSI exhibits good thermal stability and can be vacuum distilled without decomposition; it is widely used in the pharmaceutical, pesticide, and materials science industries.

Product Description Of Tosyl Isocyanate Cas 4083-64-1

Item Specification
Melting Point 5°C
Boiling Point 280°C/760 mmHg
Density 1.291 g/mL at 25 °C (lit.)
Vapor pressure 1 mm Hg (100 °C)
Flash Point 227.6±9.3 °C
Refractive Index n20/D 1.534 (lit.)
Flash point 110°C–121°C
Specific gravity 1.291
Odor Pungent
Solubility Soluble in halogenated hydrocarbons, aromatics, and ether solvents; reacts violently with water or protic solvents.

Product Application Of Tosyl Isocyanate Cas 4083-64-1

  1. Pharmaceutical synthesis: Serves as the key intermediate Tosyl Isocyanate (PTSI) for the preparation of metazolazine (an antihypertensive drug), antibiotics, anticancer drugs, etc.
  2. Pesticide synthesis: PTSI is used to synthesize agricultural chemicals such as herbicides and fungicides
  3. Materials Science: Used as a cross-linking agent in polyurethane coatings, sealants, and adhesives, as well as for polymer modification
  4. Analytical Chemistry: Used as a derivatization reagent (p-Toluenesulfonyl Isocyanate) in pharmaceutical analysis, such as the detection of diethylene glycol and propylene glycol
  5. Organic Synthesis: Used for the efficient synthesis of carbamates, ureas, and urea derivatives, as well as in stereoselective reactions and the construction of heterocyclic compounds
Packaging Method Of Tosyl Isocyanate Cas 4083-64-1
25L - plastic barrel
Ton barrel
250L-barrel
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