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Trimethylsilyl triflate (TMSOTf) is a highly reactive organosilicon reagent with a molecular formula of C4H9F3O3SSi, MW: 222.26. At room temperature, it is a colorless to pale yellow transparent liquid with strong Lewis acidity and silylation capability. It is extremely sensitive to water and prone to hydrolysis. It serves as a core silylation reagent, catalyst, and cationic initiator in the field of organic synthesis and is widely used in the fine chemical industries, including pharmaceuticals, pesticides, and materials.
| Item | Specification |
| Melting Point | -25°C |
| Boiling Point | 77°C/80 mmHg(lit.) |
| Density | 1.228 g/mL at 25°C(lit.) |
| Flash point | 78°F(25.6°C) |
| Vapor pressure | 4.7 hPa(20°C) |
| Refractive index | n 20/D 1.36(lit.) |
| Solubility | Miscible with alcohols, ethers, benzene, dichloromethane, etc.; decomposes immediately upon contact with water. |
| Sensitivity | Highly sensitive to water; must be stored and used under anhydrous and anoxic conditions. |
Organic Synthesis: Trimethylsilyl triflate is used for silylation of hydroxyl and amino groups, while also acting as a strong Lewis acid to catalyze various reactions such as condensation, glycosylation, and substitution.
Pharmaceuticals and Pesticides: Trimethylsilyl trifluoromethanesulfonate is used in the synthesis of anticancer and antiviral drugs as well as agricultural chemicals to optimize reaction pathways and improve product yield and selectivity.
Polymer Materials: Trimethylsilyl triflate serves as a cationic polymerization initiator for the preparation of specialty polymers, liquid crystal materials, and functional additives for batteries.
Laboratory Analysis: Trimethylsilyl trifluoromethanesulfonate is used for sample derivatization and as a common reagent in organic chemistry research.
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