
Tropinone, with the MF: C8H3NO MW: 139.2, is a white, needle-like crystal. Commercially available products are typically pale yellow to light brown in color. It is stable at room temperature, slightly soluble in water, and readily soluble in organic solvents such as ethanol and diethyl ether. It exhibits weak basicity and sublimates readily when heated. It is primarily used as a pharmaceutical synthesis intermediate, in the preparation of alkaloids, as a raw material in organic chemistry, and as a laboratory analytical reagent.
| Item | Specification |
| Melting Point | 40–44 °C |
| Boiling Point | 113 °C (25 mmHg) |
| Density | 1.086 g/cm³ |
| Flash point | 90 °C |
| Refractive index | 1.4980 (n20/D) |
| Vapor pressure | 0.1 mmHg (25°C) |
| Acidity coefficient | Weakly alkaline, stable under normal temperature and sealed conditions |
| Solubility | Freely soluble in methanol, chloroform, and ethanol; slightly soluble in water; insoluble in petroleum ether. |
Pharmaceutical Synthesis Intermediates (Core Application): Tropinone is used in the synthesis of scopolamine alkaloids such as atropine, scopolamine, and hyoscyamine.
Fine Organic Chemistry: Serves as a raw material for the synthesis of scopolamine derivatives, used in the preparation of heterocyclic compounds and alkaloid-based fine chemicals.
Research and Experimental Applications: It is used as reagents for organic synthesis research, reference standards for biochemical analysis, and basic raw materials for pharmacological experiments.
Biochemical Research: Applied to the study of natural alkaloid metabolic mechanisms and the research and development of novel medicinal molecules.
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