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4 Bromoacetanilide, also known as p-bromoacetanilide, has the chemical name N-(4-bromophenyl)acetamide, with the molecular formula C₈H₈BrNO and a molecular weight of 214.06. is a white to pale beige crystalline solid at room temperature. It contains a benzene ring, an acetylamine group, and a bromine atom. As an important aromatic amide intermediate in organic synthesis, it can undergo various substitution and coupling reactions and is widely used in the fine chemical industry, including pharmaceuticals, dyes, and pesticides.
| Item | Specification |
| Melting Point | 167–169°C |
| Boiling point | 353.4°C (estimate) |
| Density | 1.72 g/cm³ (25°C) |
| Flash point | 167.6°C |
| Vapor pressure | N/A |
| Refractive index | 1.6120 (estimate) |
| Solubility | Soluble in benzene, chloroform, and ethyl acetate; moderately soluble in ethanol; slightly soluble in hot water (0.5 g/L); practically insoluble in cold water. |
| Stability | Good thermal stability; undergoes hydrolysis, bromination, and coupling reactions. |
Pharmaceutical synthesis: 4-Bromoacetanilide is used as an intermediate for anti-inflammatory, antipyretic, and antihistamine drugs; also serves as an internal standard and reference standard for drug testing.
Dyes and pigments: P-Bromoacetanilide is used in the synthesis of azo and disperse dyes as well as organic pigments to enhance the lightfastness and colorfastness of finished products.
Pesticide manufacturing: P-Bromoacetanilide is used in the preparation of agricultural chemicals such as herbicides, fungicides, and plant growth regulators.
Organic chemistry: 4 Bromoacetanilide serves as a synthetic building block for aromatic compounds, participates in various coupling reactions, and is also used for calibration in chromatographic analysis.
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