


Cas 495-18-1 /Benzohydroxamic acid (also known as benzyl hydroxyoxoacetic acid or N-hydroxybenzamide) is an aromatic hydroxyoxoacetic acid organic compound with the molecular formula C₇H₇NO₂ and a molecular weight of 137.14. At room temperature, it appears as white orthorhombic plate-like or needle-like crystals. It is slightly soluble in water but readily soluble in polar solvents such as ethanol and ethyl acetate. Its molecular structure contains a benzene ring and a hydroxamic acid group (-CONHOH), endowing it with strong chelating and reducing properties. It is widely used in mineral flotation, analytical testing, pharmaceutical synthesis, and industrial water treatment.
| Item | Specification |
| Melting Point | 131-132°C |
| Boiling point | 213–214 °C (lit.) |
| Density | 1.15 g/mL at 25 °C (lit.) |
| Flash point | 210 °F |
| Vapor pressure | 1.0×10⁻⁵ mmHg (1.33×10⁻³ Pa) at 25°C |
| Refractive index | 1.578 (20°C) |
| Solubility in water | 22 g/L (6°C); aqueous solution is acidic |
| Stability | Sensitive to humidity and temperature; avoid contact with strong oxidizing agents. |
Analytical Chemistry: As a metal indicator/chelator for Fe³⁺, Al³⁺, used in spectrophotometric determination.
Pharmaceutical Intermediates: For synthesis of HDAC inhibitors, antifungal/antitumor agents.
Agriculture: As chitin deacetylase inhibitor, antifungal agent for crop disease control.
Organic Synthesis: Reagent for amidation, cross‑linking, and heterocyclic synthesis.
Material Science: Benzohydroxamic acid is used in polymer additives, metal surface treatment, and corrosion inhibition
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