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4 Hydroxyacetophenone (p-Hydroxyacetophenone, piceol) is an aromatic ketone compound with the chemical name 1-(4-hydroxyphenyl) acetone, with the molecular formula C8H8O2 and a molecular weight of 136.15. It appears as white needle-like crystals or an off-white powder and occurs naturally in Asteraceae plants such as Artemisia annua and Artemisia capillaris. Possessing both phenolic and aromatic ketone characteristics, it is mild and low in toxicity. It exhibits biological activities including cholagogue, antibacterial, and antioxidant properties, and is widely used in the pharmaceutical, cosmetic, fragrance, and organic synthesis industries.
| Item | Specification |
| Melting Point | 109-112℃ |
| Boiling point | 147-148℃(3 mmHg) |
| Density | 1.109 g/cm³ |
| Flash point | 166℃ |
| Vapor pressure | 1.08×10⁻⁵ mmHg(25℃) |
| Refractive index | 1.5570(140℃) |
| Solubility | 10 g/L (22°C); readily soluble in ethanol, diethyl ether, and acetone |
| Stability | Light-stable, heat-stable, acid- and alkali-resistant; stable in storage. |
Pharmaceutical Applications: 4 Hydroxyacetophenone is used as an intermediate in the synthesis of antipyretic and cardiovascular drugs; serves as a cholagogue and hepatoprotective agent; also used in topical antibacterial formulations for the skin.
Personal Care and Cosmetics: Acts as a mild preservative and antioxidant, soothing and repairing the skin; also serves as a fixative in fragrances.
Food Flavors: P Hydroxyacetophenone is used to formulate various natural fruit-based flavorings and as a food antioxidant to extend the shelf life of ingredients.
Fine Chemicals: 4-Acetylphenol is used in the production of pesticides and functional dyes, and also serves as a standard reagent for chemical analysis and testing.
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