


Dimethylformamide, abbreviated as DMF,is a colorless, transparent, high-boiling-point liquid with a faint amine odor. Molecular Formula: C₃H₇NO MW: 73.09. It is a compound formed by replacing the hydroxyl group of formic acid with a dimethylamino group. As a highly polar, high-boiling-point non-protonic organic solvent, it possesses exceptional dissolving power and is hailed as the “universal solvent.”
| Item | Specification |
| Melting point | -61°C (lit.) |
| Boiling point | 153°C (lit.) |
| Density | 0.944 g/mL (lit.) |
| Vapor Density | 2.5 (vs air) |
| Vapor Pressure | 2.7 mmHg (20°C) |
| Refractive Index | n20/D 1.430 (lit.) |
| Flash Point | 57.78°C |
| Acidity coefficient (pKa) | -0.44 ± 0.70 (Predicted) |
| APHA | ≤15 |
| Specific rotation | 0.94º |
| Relative polarity | 0.386 |
| Odor Threshold | 1.8 ppm |
| Explosive Limit | 2.2–16% (V) |
| Solubility | Miscible with water, ethanol, diethyl ether, acetone, benzene, and most organic solvents; dissolves polymers, resins, inorganic salts, and various substances. |
Chemical Industry: N,N-Dimethylformamide serves as a reaction solvent (e.g., Suzuki coupling, nucleophilic substitution reactions) and extractant for synthesizing polymers like polyurethane, polyamide, and acrylic esters
Pharmaceutical Industry: N,N-Dimethylformamide dissolves drug intermediates, synthesizes antibiotics (e.g., cephalosporins), vitamins, hormones, and serves as a solvent in pharmaceutical formulations
Materials Industry: It dissolves resins like polyvinyl chloride (PVC) and polyacrylonitrile (PAN), used in spinning (e.g., acrylic fibers), film manufacturing, and coating formulations.
Electronics: N,N-Dimethylformamide serves as a photoresist solvent and electronic component cleaning solution, supporting semiconductor and liquid crystal display manufacturing.
Other: It is employed in dye and pigment dissolution, dyeing processes, and the extraction and separation of metal ions.
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